Funcion de la macula densa pdf file

Effects of filtration rate on the glomerular barrier and clearance of. The renal commission of the international union of physiological sciences iups. In the kidney, the macula densa is an area of closely packed specialized cells lining the wall of the distal tubule at the point of return of the nephron to the vascular pole of its parent glomerulus, glomerular vascular pole. Observations on the composition of glomerular urine, with. Beneath the macula densa cells, the basal lamina is thin with extensions from the cells passing through it. Macula densa definition of macula densa by medical dictionary. Sistema renina angiotensina aldosterona slideshare. Puede ser intervenida quirurgicamente mediante una. The macula densa is the thickening where the distal tubule touches the glomerulus the cells of the macula densa. Oct 15, 1999 the macula densa acts as a sensor of nacl concentration in tgf, the mechanism critical for the rapid adaptation of filtration rate to the absorptive capacity of the tubule. Role of mesangial cells in macula densa to afferent arteriole information.

The macula densa is the thickening where the distal tubule touches the glomerulus. A decrease in blood pressure results in a decreased concentration of sodium and chloride ions at the macula densa. The cells on the side of the tubule facing the glomerulus have a distinct appearance and constitute the macular densa. What is the function of the macula densa cells of the. Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions. Tratamiento del agujero macular american academy of. Learn vocabulary, terms, and more with flashcards, games, and other study tools. These cells sense the nacl content of the tubule and make changes to gfr appropriately. This is due to reduced filtration by the glomerulus. The tubuloglomerular feedback mechanism of renal autoregulation is the key function of the macula densa.

Oct 03, 2017 the tubuloglomerular feedback mechanism of renal autoregulation is the key function of the macula densa. Laldosterone agit sur le metabolisme des electrolytes. The macula densa cells are a small subset of approximately 20 cells per nephron at the distal end of the ctal of the loop of henle. Apr 22, 2016 sistema renina angiotensina aldosterona 1. Macula densa medical definition merriamwebster medical. Macula densa sensing and signaling mechanisms of renin release. In the kidney, the macula densa is an area of closely packed specialized cells lining the wall of the distal tubule, at the point where the thick ascending limb of the loop of henle meets the distal convoluted tubule. Cox2, the source of macula densa derived prostaglandins mediating renin expression and release by the juxtaglomerular apparatus, is present at low but detectable levels in the macula densa under normal homeostatic conditions. As the distal proximal tubule rises from the renal medulla, it makes close contact with the glomerulus.